ZenoWell
Vagus Nerve Stimulator
Building the Future of AI-Powered Neurotechnology with ZenoWell
As an authorized distributor of ZenoWell, we are committed to expanding access to innovative neurotechnology and building a community focused on better health and well-being.
ZenoWell is advancing personalized neuromodulation through its innovative AI-powered, closed-loop transcutaneous auricular vagus nerve stimulation (taVNS) technology. By combining intelligent technology with non-invasive neurostimulation, ZenoWell aims to make advanced neuromodulation more accessible, personalized, and convenient for everyday use.
Together with ZenoWell, we are bringing the next generation of wearable neurotechnology closer to individuals, healthcare professionals, and communities.
Non-Pharmaceutical & Long-Term Solutions
ZenoWell delivers drug-free, sustainable solutions specifically designed for:
Sleep Disorders
Headaches
Mental Health
Recovery & Balance
Cognitive Enhancement
Pain & Fatigue Management
Mindfulness & Meditation
Four Mechanisms of ZenoWell’s taVNS
Support ANS Balance & Neurotransmitter Modulation
Supports parasympathetic activity while helping regulate excessive sympathetic activity, promoting a more balanced autonomic nervous system (ANS) response.
Vagus nerve stimulation may also influence pathways involved in the regulation of key neurotransmitters and neurochemicals, including serotonin, dopamine, melatonin, and endorphins.
Modulate Brain Activity & Support Anti-Inflammatory Responses
Supports the regulation of brain activity and functional connectivity in regions associated with sleep, stress, and pain processing.
Vagus nerve stimulation may also help modulate the body’s inflammatory response through key neuroimmune and anti-inflammatory pathways.
Experience Lasting Benefits
Scientifically designed electrodes and advanced materials provide precise, consistent, and comfortable stimulation for an enhanced user experience.
With consistent use, benefits may progressively develop over time:
7 Days: Supports faster sleep onset
14 Days: Supports better sleep quality and stress management
21 Days: Promotes a greater sense of physical and mental well-being
Individual experiences and results may vary.
Beyond Better Sleep
ZenoWell harnesses advanced neuromodulation technology to support your body’s natural balance, relaxation, and recovery—extending the benefits beyond better sleep to everyday well-being.
Designed to complement your daily wellness routine, ZenoWell is your companion for long-term well-being.
It shifts autonomic balance toward parasympathetic that slowing HR, lowering arousal; regulates hyperarousal in salience and default mode networks; and restores GABAergic and noradrenergic tone implicated in sleep-wake regulation.
Science
The vagus nerve is the longest cranial nerve in the body and a key part of the parasympathetic nervous system, often known as the body’s “rest and digest” system.
It acts as an important communication pathway between the brain and major organs, helping regulate involuntary functions such as heart rate, digestion and immune responses. It also plays an important role in maintaining balance between the parasympathetic (“rest and digest”) and sympathetic (“fight or flight”) branches of the autonomic nervous system (ANS).
• Transcutaneous Auricular Vagus Nerve Stimulation
A non-invasive neuromodulation technique that stimulates the auricular branch of the vagus nerve (ABVN), which is accessible through the outer ear.
• Clinical & Wellness Applications:
Anxiety and depression, Insomnia and sleep disorders, Chronic pain, Headache, Inflammatory conditions (e.g., IBS, arthritis), Post-stroke recovery, Cognitive enhancement / mental focus.
Mechanisms underlying transcutaneous auricular vagus nerve stimulation:
1. Autonomic Nervous System Modulation
• Enhance parasympathetic excitability
• Suppress sympathetic hyperactivity
• Improve sympathetic-parasympathetic balance
2. Brainstem Activity Modulation
• Nucleus tractus solitarius Locus coeruleus, raphe nuclei
• Periaqueductal gray matter
• Thalamo-cortical circuits
3. Enhanced Neuroplasticity
• Noradrenergic, dopaminergic, and GABAergic systems
• Brain-derived neurotrophic factor (BDNF)
• Increased cerebral blood flow reperfusion
4. Anti-inflammatory Effects
• HPA axis anti-inflammatory pathway
• Cholinergic anti-inflammatory pathway
• Splenic immune anti-inflammation
Research & Scientific Resources
Explore scientific research and publications related to ZenoWell, together with relevant studies and research from ZenoWell and its research partners.
ZenoWell’s ongoing research on the vagus nerve – The expert team at ZenoWell has conducted numerous cutting-edge research on the vagus nerve, and some of the ongoing studies are as follows:
1. Sleep:
– Closed-Loop Non-Invasive Vagus Nerve Modulation for Improving Adult Insomnia;
– Non-Invasive Vagus Nerve Stimulation for Improving Sleep Disorders in Adult Hemodialysis Patients: A Randomized Controlled Trial;
– Transcutaneous Auricular Vagus Nerve Stimulation for Improving Sleep Disorders After Lumbar Fusion Surgery: A Randomized Controlled Trial;
– Respiratory-Gated Targeted Closed-Loop Vagus Nerve Modulation for Temporomandibular Disorders With Sleep Disturbance: A Single-Center Randomized Single- Blind Controlled Trial
2. Stress & Emotional Balance:
– Closed-Loop Vagus Nerve Modulation for Emotion Regulation;
– Personalized TaVNS and Meditation: A High-Density EEG Exploration;
– Multimodal Closed-Loop Neuromodulation With taVNS for Improving Post-Stroke Emotional and Motor Dysfunction: Mechanisms and Clinical Study
3. Gastrointestinal Health:
– Transcutaneous Auricular Vagus Nerve Stimulation for Improving Gastrointestinal Function After Lumbar Fusion Surgery: Randomized Controlled Trial;
– Effects and Mechanisms of Transauricular Vagus Nerve Stimulation via the Brain–Vagus–Gut Axis in Patients With Alzheimer’s Disease-Related Mild Cognitive Impairment
4. Pain:
– Non-Invasive Vagus Nerve Stimulation for the Prevention and Treatment of Primary Headache: A Single-Center Single-Arm Clinical Study;
– Transcutaneous Auricular Vagus Nerve Stimulation for Migraine: A Randomized Controlled Clinical Study;
– Assessing the Efficacy of Non-Invasive Vagus Nerve Stimulation in the Treatment of Chronic Migraine: A Comprehensive Study Protocol;
– Respiratory-Gated Closed-Loop Vagus Nerve Stimulation for Neuropathic Pain: A Randomized Controlled Clinical Study;
– Effects and Neural Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation on Central Sensitization in Chronic Low Back Pain
5. Stroke Rehabilitation:
– Promotion and Application of an Intelligent Platform for Secondary Stroke Prevention Management;
– Transauricular Vagus Nerve Stimulation Combined With Functional Electrical Stimulation for Upper-Limb Recovery During the Flaccid Stage;
– EMG-Triggered Closed-Loop Vagus Nerve Electrical Stimulation for Improving Swallowing Function: A Single-Center Randomized Double-Blind Controlled Clinical Study;
– Transcutaneous Auricular Vagus Nerve Stimulation for Improving Upper-Limb Motor Function After Stroke: A Multicenter Randomized Double-Blind Controlled Clinical Study;
– Therapeutic Effects of EMG-Gated Vagus Nerve Electrical Stimulation on Upper-Limb Motor Function After Stroke; Targeted Closed-Loop Vagus Nerve Modulation in Stroke Rehabilitation;
– Transcutaneous Auricular Vagus Nerve Stimulation Combined With Upper-Limb Robotic Training for Post-Stroke Upper-Limb Functional Recovery;
– Vagus Nerve-Mediated Brain–Computer Interface Closed-Loop Feedback for Neural Remodeling in Post-Stroke Motor Dysfunction;
– Hyperbaric Oxygen and Brain–Computer Interface Intervention for Neural Remodeling in Post-Stroke Functional Impairment
– EMG-Closed-Loop Vagus Nerve Modulation for Improving Swallowing Function in Stroke Patients;
– Transcutaneous Auricular Vagus Nerve Stimulation for Acute Intervention in Patients With Hemorrhagic Brain Injury
6. Disorders of Consciousness:
– Respiratory-Gated Closed-Loop Transcutaneous Auricular Vagus Nerve Stimulation for Arousal Promotion in Coma: A Randomized Double-Blind Controlled Clinical Study;
– Comparative Study of rTMS and taVNS for Arousal Therapy in Patients With Chronic Disorders of Consciousness
7. Neuromodulation:
– Development of Low-Impedance High-Entropy Alloy Dry EEG Electrodes and Validation in Brain–Computer Interface Applications;
– Wearable fNIRS Near-Infrared Brain Functional Imaging System;
– Effects of Respiratory-Gated Closed-Loop Vagus Nerve Stimulation on the Locus Coeruleus and Brain Circuits in Mice;
– Random Current Vestibular Stimulation for Improving Obstacle-Crossing Motor Performance in Adolescents With Idiopathic Scoliosis;
– Integration of Neuromodulation and Rehabilitation Robotics;
– Closed-Loop Vagus Nerve Modulation for Neurorehabilitation;
– Brain–Computer Interface Closed-Loop Vagus Nerve Modulation System
– Brain–Computer Interface Closed-Loop Neuromodulation System;
– Transcutaneous Auricular Vagus Nerve Stimulation Combined With Slow Breathing for Autonomic Nervous System Regulation;
– Cervical Vagus Nerve Modulation for Cognitive Improvement
8. Women’s Health:
– taVNS Closed-Loop Intervention After Frozen Embryo Transfer in Patients With Qi Stagnation and Blood Stasis-Type Infertility: A Clinical Study;
– HerRelief Wearables: Applying Earphone-Like Wearable Devices for Endometriosis Therapy in Women
9. Cardiovascular Health:
– Reproducibility Study of Transcutaneous Auricular Vagus Nerve Stimulation in Modulating Heart Rate Variability;
– Animal Study of Transcutaneous Auricular Vagus Nerve Stimulation for Hypertension Regulation
10. Addition & Behavioural Health:
– Transcutaneous Auricular Vagus Nerve Stimulation for Modulating Addiction-Related Withdrawal Responses
11. Elderly Health:
– Key Technologies for Elderly Health Promotion: Intelligent Risk Control Technologies for Disability Prevention in Older Adults and Demonstration Applications;
– Respiratory-Gated Closed-Loop Vagus Nerve Stimulation for Improving Non-Motor Symptoms in Parkinson’s Disease
– Cognitive Training Combined With Vagus Nerve Stimulation for Cognitive Impairment: Development and Clinical Validation of a Personalized Rehabilitation System;
– Effects and Mechanisms of Transauricular Vagus Nerve Stimulation via the Brain–Vagus–Gut Axis in Patients With Alzheimer’s Disease-Related Mild Cognitive Impairment
12. 50+ Papers Are Currently Under Research
Contact Us
For access to available research papers and supporting scientific materials, please contact our team, and we will be happy to assist you.<br>
Certification and Safety
ZenoWell is certified by CE, FCC and RoHS, which means:
- It has been audited by official regulators.
- It is based on rigorous scientific evidence.
- The benefits outweigh the risks.
- It has demonstrated clinical efficacy.
- It has strict quality management systems.
- Be sure to read important safety information before use.
- ZenoWell has been evaluated in randomised placebo controlled clinical trials and now used widely with over 2M patient sessions and 0 serious adverse events have been reported.
- Its safety has been confirmed in multiple clinical studies.
Buy Now
Email: enquiry@anvision.com.sg
Delivery Terms and Conditions
Customers are entitled to complimentary local delivery.
Delivery service is limited within Singapore. For enquiries regarding delivery to special or restricted locations, please contact us for assistance. Delivery service is not available for non-fixed or temporary addresses.
Delivery services are available Monday to Saturday, from 9:00 AM to 6:00 PM, excluding Sundays and Public Holidays.
After your order has been confirmed, our team will contact you within two (2) working days to arrange and confirm the delivery date and time. Under normal circumstances, orders within Singapore will be delivered to the registered delivery address within approximately five (5) working days after the order has been placed.
Please note that delivery schedules may be affected if there are delays in payment processing, including credit card authorization or bank approval. In such cases, the delivery date may be adjusted accordingly.
Delivery times may also be subject to delays, suspension, or rescheduling due to circumstances beyond our control, including but not limited to traffic conditions, location accessibility, weather conditions, or other unforeseen events. Anvision Healthtech Pte Ltd shall not be held responsible for any such delays or changes in the delivery schedule.
If you need to change the delivery address, delivery date/time, or modify the original sales order, please contact Anvision Healthtech Pte Ltd Customer Service at least 24 hours before the scheduled delivery time during our service hours of 9:00 AM to 6:00 PM (excluding Sundays and Public Holidays).
If the delivery personnel are unable to complete the delivery or obtain a recipient’s signature due to security restrictions or other issues related to the delivery location, Anvision Healthtech Pte Ltd reserves the right to request that the customer collect the goods directly from our staff, without arranging further delivery attempts.
In the event of any dispute, Anvision Healthtech Pte Ltd reserves the right of final decision.
Exchange Policy
If the requested replacement item is out of stock, a refund will be processed in accordance with our Refund Policy.
A valid proof of purchase or receipt is required for any exchange request.
Anvision Healthtech Pte Ltd reserves the right to decline any exchange request if the product shows signs of physical damage, misuse, missing components, or incomplete accessories.
7-Day Exchange Guarantee
Upon receiving your order, it is the customer’s responsibility to inspect the product for any visible damage and verify that all accessories are included.
If the product is found to have manufacturing defects or quality issues that do not meet production standards, customers may request an exchange within seven (7) days from the date of delivery.
To initiate an exchange, customers must contact Anvision Healthtech Customer Service to register the request and arrange the exchange process.
If the product is still within the warranty period after the 7-day exchange period, customers may continue to enjoy the warranty service provided by the manufacturer or authorised agent, and the product may be returned for repair according to the applicable warranty terms.
Conditions for Exchange
Products eligible for exchange must meet the following conditions:
• The product must be returned with complete original packaging, accessories, and user manuals.
• The product must not show signs of damage, scratches, misuse, or water exposure.
• The product must not have been registered for warranty online with the manufacturer or supplier.
• The product must not have been previously repaired or modified.
• Exchange requests based solely on personal preference, change of mind, or incorrect product selection will not be accepted.
Final Decision
In the event of any dispute, Anvision Healthtech Pte Ltd reserves the right of final decision.
Product Warranty
Devices distributed by Anvision Healthtech Pte Ltd are covered by a limited warranty of twelve (12) months from the date of purchase, unless otherwise specified.
This warranty covers:
• Manufacturing defects in hardware components
• Device malfunction under normal usage conditions
• Faults related to original product workmanship
The warranty does not cover:
• Damage caused by improper installation or misuse
• Unauthorized modification or repair of the device
• Damage resulting from accidents, water exposure, or external factors
• Normal wear and tear of consumable components
If a product is determined to be defective within the warranty period, Anvision Healthtech may provide:
• Repair of the defective device, or
• Replacement with an equivalent product, at our discretion.
Customers may be required to provide proof of purchase and product serial numbers when submitting warranty claims.
Force Majeure
Anvision Healthtech Pte Ltd shall not be held liable for any failure or delay in providing services due to force majeure events, including but not limited to natural disasters, acts of God, government restrictions, pandemics, or any other circumstances beyond our reasonable control.